Transcriptional Regulation of Neuronal-specific Gene Expression
- VernacularTitle:神经系统特异表达基因调控机理的研究进展
- Author:
Jin LIU
;
Jiangang YUAN
;
Boqin QIANG
- Publication Type:Journal Article
- From:
Progress in Biochemistry and Biophysics
2001;28(1):7-10
- CountryChina
- Language:Chinese
-
Abstract:
The differentiating of neurons and other distinct cell types during embryonic development requires the selective activation or repressing of many different sets of genes. Gene expression patterns in neurons are modulated by multiple extracellular and intracellular stimuli. The transcriptional regulation of individual gene is mediated by small DNA sequences such as silencer and enhancer, and the expression pattern can be determined by the integration of the effects of a very large number of these cis-acting elements. These DNA elements either activate or repress promoter activity depending upon the nature of the transcription factors that bind to them. It is possible that there are different regulatory mechanisms of gene expression in the nerve system.
