Focal Adhesion Kinase
- VernacularTitle:焦点粘着激酶的研究进展
- Author:
Guodong TIE
;
Enkui DUAN
;
Xingxu ZHAO
- Publication Type:Journal Article
- From:
Progress in Biochemistry and Biophysics
2001;28(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion kinase is a non-receptor protein tyrosine kinase with molecular weight 125 ku and regarded as the foundmental molecule of integrin-dependent signal transduction pathway. Active focal adhesion kinase regulates cell adhesion, migration, proliferation and differentiation by interacting with Src family kinase, phosphatidylinositol-3 kinase, cytoskeletal proteins, Graf and adoptor proteins through the phosphorylated tyrosines and the proline-rich sequences.
