Cell Senescence and the Enzyme System for Surveillanceand Repair of DNA Damage
- VernacularTitle:DNA损伤监测及修复相关酶与细胞衰老
- Author:
Ying LUO
;
Jianli SUI
;
Yi TIE
- Publication Type:Journal Article
- From:
Progress in Biochemistry and Biophysics
2001;28(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Senescence is one of the most important phenomena in cells' life. It is hold by one of hypothesis for cell senescence that residue DNA damages of a cell will accelerate its senescence.The normal function of surveillance and repair system for DNA damage is highly related with the senescence regulation of a cell. As a result, research of senescence regulation role of enzymes related for surveillance and repair of DNA damage, such as PARP, DNA-PK, ATM, p53, etc., will discover the inner relation between stress response of cell to DNA damage, regulation of DNA damage repair and cell senescence. That may be helpful for research of anti-aging and treatment of tumor by regulation of senescence of tumor cells.
