An Experimental Study on the Treatment of Blast Deafness by Sodium Salicylale
- VernacularTitle:水杨酸钠对爆震性聋治疗作用的实验研究
- Author:
Jinling WANG
;
Shunli LIU
;
Xianming CHEN
- Publication Type:Journal Article
- From:
Journal of Audiology and Speech Pathology
2001;9(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of treatment and mechanism of sodium salicylate on blast deafness. Methods Guinea pigs were divided into blast group, blast plus sodium Salicylate group and sodium solicylate group. The animals in the blast group were exposed to blast average peak pressure 176.7 dB(SPL); sodium salicylate was injected IP 400 mg/kg,1/d. Monitoring ABR threshold, the value of MDA of and counting the number of hair cells on the cochlea preparation, SEM for hair cells was observed. Results The ABR threshold shift in the blast group was 46.75±13.56 dB，38.0±12.4 dB,35.5±10.67 dB，41.5±12.57 dB,33.75±8.42 dB, post-blast 1 d，3 d，1 w，2 w,4 w respectively. And that of the blast plus sodium salicylate was 46.65±11.7 dB，38.25±9.52 dB,30.5±9.17 dB,30.0±9.17 dB,23.0±6.57 dB. The two groups differed significantly at 1 w，2 w，4 w(P＜0.05). The value of MDA differed significantly at 2 w,4 w(P＜0.05). And the hair cells lost also differed significantly. It was observed that sodium salicylated can raise the ABR thresbold temporarily 24 hrs during simple sodium salicylate adminastration. However it recovered 14 hrs after the injection.Conclusion Sodium salicylate can partially attenuate the hearing loss caused by blast. It is probable that sodium salicylate can clear peroxicative produced during blast and therefore protect hair cells and make hearing loss partially recover.
