EXPRESSION OF IL-2 GENE IN INJURED TISSUE OF MAXILLOFACIAL FIREARM TRAUMA
- VernacularTitle:颌面部火器伤损伤组织中白介素2基因的表达
- Author:
Junzhi QIN
;
Shuxia ZHOU
;
Yinqiu LIU
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
2001;26(1):33-35
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the temporal variation of cell-mediated immunity in injured tissue of maxillofacial firearm trauma. Cells expressing messenger RNA(mRNA) for IL-2 were demonstrated by dot blotting and in situ hybrization in injured tissue of maxillofacial trauma inflicted by bullet, in conjunction with immunohistochemistry for IL-2 in normal and postinjury conditions. It was found that, apart from a transient eleratim in level within 24h post injury, both IL-2 production and IL-2 mRNA expression were consistently suppressed in cells at the site of the wound compared with the normal. The changes in the tissues of indirect injury by the projectile were significant. These results indicate that the cell-mediated immunity was suppressed in maxillofacial firearm trauma and the principal cellular abnormalities that resulted in altered T cell activation and IL-2 production postinjury was downregulation of mRNA before IL-2 gene transcription. It also suggested that the indirect injury by projectile contribute mainly to the depression of cell-mediated immunity.
