Anti-Arrythmic Effects of L-Dicentrine
- VernacularTitle:左旋荷包牡丹碱抗实验性心律失常的研究
- Author:
Huilan LI
;
Mu LI
;
Xinlin LIU
;
Shanguo SU
;
Yi HAN
- Publication Type:Journal Article
- From:
Journal of Kunming Medical University
2001;22(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
To observe Antiarrhythmic effects of L-dicentrine.Methods using experimented model of arrhythmials.Results: L-dicentrine iv l0 mg/kg could convert BacRinduccd arrhythmia into sinus rhythm in rats,and could significantly increase the tolerant dose of aconine to produce Ventricular fibrillation (VF) and Cardiac [rrest (ca) in rats. The drug could also decrease the incidence of VF and CP by cardiac rats and by chloroform in mice. L-dicelltrine had protective effects on ouabain ind uced Arrhythmias in guined pigs and on adrenalice induced arrhythmias in rabbit s . The drug might also inhibit the arrhymias induced by stimulation ofhypothaplu s. Conclusion: L-dicenirine have significant antiarrhythmic properties.