Effects of 1-acetylforskolin on Intraocular Pressure in Rabbits and Men
- VernacularTitle:1-乙酰基佛司可林对兔及人眼内压的影响
- Author:
Weimin YANG
;
Xinhua LI
;
Zhihe CHEN
;
Yidan LIU
;
Linhui NIE
;
Qiduan JIN
- Publication Type:Journal Article
- From:
Journal of Kunming Medical University
2001;22(1):14-16
- CountryChina
- Language:Chinese
-
Abstract:
To investigate effects of l% l-acetylforskoin (l-aF) suspension eye-drops administeredtopically on intraocular pressure (IOP) in rabbits and men, and observe the loca l irritation of the drug． l% l-aF suspension eye-drops was prepared and was instilled into one of e yes while the corresponding vehicle into the contralateral eye as control． IOP was measured b y pneumatonometer before and after administration． l%1-aF suspension eye-drops s ig nificantly reduced IOP in rabbits reaching the maximum reduction of 2.2 mmHg and lasting a t least 3 hours． But it didnt show significant effects in men． There was little local irritati on neither in rabbits nor in men． l% l-aF suspension eye-drops significantly reduced IOP in normal rabbit s, but not in men． No local irritation was observed in rabbits and in men．
