Change of synaptophysin in rat model hippocampal formation after pentylenetetrazol kindling
- VernacularTitle:戊四氮点燃大鼠模型海马结构内突触体素的变化
- Author:
Yabo FENG
;
Hong YAO
;
Zhaofu CHI
- Publication Type:Journal Article
- From:
Journal of Clinical Neurology
2001;14(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the plasticity of hippocampal formation in epilepsy.Methods The optical density (OD)of synaptophysin positive immunoreactive product was examined by image pattern analysis instrument in hippocampus of pentylenetetrazol induced kindling epileptic rats. The examined areas included CA1,CA3 and the dentate gyrus.Results The OD of synaptophysin positive immunoreactive product in hippocampal formation of kindling group was higher than the controls,especially in the mossy fiber layer of the area CA3 and the inner molecular layer in the dentate gyrus. Conclusion The change of synaptophysin resulted from kindling, it also could result in the molecular elements of kindling maintenance.
