Study on association of the Beta 3-adrenergic receptor gene wit h obesity
- VernacularTitle:β3-肾上腺素能受体基因与肥胖关系
- Author:
Yu CHEN
;
Ling ZHOU
;
Yaochu XU
;
Hongbing SHEN
;
Rongbin YU
;
Juying NIU
- Publication Type:Journal Article
- From:
Chinese Journal of Disease Control & Prevention
2001;5(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association betwee n the β3-adrenergic receptor gene (β3-AR) and obesity. Methods 147 patients with obesity and 106 controls were selected. Genotype of the β 3-AR was determined by polymerase chain reaction (PCR) and restriction fragme nt length polymorphism methods (RFLP). Body mass index (BMI) was detected. Results The frequency of Arg64 allele of β3-AR gene in the obesit y g roup (20.3%) was significantly higher than those in the control group (10.2%) ( P=0.001) . The distribution of Trp64Arg and Arg64Arg genotype in the patient group (38.7% and 0.9%) were both higher than that in the control group (19.0% and 0.7%). In the female subj ects, the Trp64Arg mutation and frequency of Arg64 allele of the β3-AR gene in the obesity group(40.6% and 20.3%) were also higher than those in control (16 . 7% and 9.5%)(P<0.01). Conclusions These results suggest th at the Trp64Arg mutation of the β3-adrenergic-receptor gene may be associat ed with increased body fat.
