Experimental Study of Effect of Aluminum on Learning and Memory and the Changes of Synaptic Interface Constructure in Hippocampus CA3 Area in Rats
- VernacularTitle:铝对大鼠学习记忆的影响及海马CA3区突触界面结构改变的实验研究
- Author:
Yuhong JING
;
Shenyuan FENG
;
Fei WANG
- Publication Type:Journal Article
- From:
Progress of Anatomical Sciences
2001;7(1):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of aluminum on learning and memory and the synaptic interface constructure in hippocampus CA3 area in rats. Methods The electrical maze were used to test the behavioral reaction of rats. Some parameters of synaptic interface structure were measured by the method of ultrastructural quantitative analysis in hippocampus CA3 area in the rats. Results The time coming through the E-maze prolonged siginificantly in the experimental group compared with the normal control (P＜0.01), meanwhile the cyto-apparatus demonstrated the pathogenetic changes. Amounts of synapse obviously reduced and the post-synaptic density turned thinner in experimental group than in the control group (P＜0.01). Conclusion Aluminum can cause the malfunction on learning and memory, which related to the plastic of synapse.
