The Effect of Cilazapril on the Motor and Cognitive Function in Cerebra l Infarction with Hypertension.
- VernacularTitle:西拉普利对脑梗塞伴高血压患者运动及认知功能的影响
- Author:
Jianhong ZHANG
;
Jianzhong FAN
;
Zhencai WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Hypertension
2001;9(1):41-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of cilazapril on motor and cognitive function in hypertension with brain stroke. Method 42 hypertensive patients with stroke were divided into cilazapril treatment group(22 cases) and traditi onal treatment group (20 cases). The cilazapril group was treated with Inhibace 2.5 mg～5 mg daily. The traditional group was treated with nifedipine and/or di uretic. The blood pressure was measured twice a day during the treatment course. The activity of daily living (ADL), motor and cognitive function were assessed with Barthel index, Fugl-Meyer and MMSE assessment respectively before and 6 we eks after treatment. Results There were no difference between the two groups on blood pressure effectiveness, but blood pressure was more stable in the cilazapril gro up. Improvement of ADL and lower limb motor function in cilazapril treatment gro up were improved significantly than those of traditional treatment group(P<0.05). Although there was no difference between the two groups in the total value of cognitive function assessment, but the directional ability and memory function in group wa s higher than those in traditional group (P<0.05). Conclusion Cilazapril can decrease blood pressure steadily and can improve the activity of daily living and cognitive function in stroke patients.
