Influence of recombinant growth hormone on protein metabolism in chronic abdominal infection
- VernacularTitle:重组人生长激素对慢性腹腔感染病人蛋白质代谢的影响
- Author:
Yuanxin LI
;
Yousheng LI
;
Jianan REN
;
Ning LI
;
Jieshou LI
- Publication Type:Journal Article
- From:
Parenteral & Enteral Nutrition
2001;8(1):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To study the ameliorated effect of recombinant growth hormone on protein metabolism in chronic abdominal infection. Methods: 20 patients were divided randomly into two groups. Patients in the control group received TPN only for 10 days, while patients in the GH groups received both rGH(13.5u/d) and TPN for 10 days. Sepsis Score grade and detection of serum Growth Hormone (GH), Insulin like growth factor-1 (IGF-1), and Insulin like growth factor binding protein- 3(IGFBP-3) were carried out on day 0 and day 11, Serum albumin, prealbumin, transferring, fibronectin and C-reaction protein were detected on day 0, day 3, day 7 and day 11, Nitrogen balance and 24-hour urine creatinine secretion were assayed daily. Results: GH, IGF-1 and IGFBP-3 in the GH group on day 11 were significantly higher than those in the GH group on day 0 and those in the control group on day 11, Serum albumin, prealbumin, transferring and fibronectin increased, while C-reaction protein decreased when patients were undertaken GH treatment, Nitrogen balance ameliorated and accumulative total nitrogen balance in the GH group was significantly higher than that in the control group, while 24-hour urine creatinine secretion decreased. Conclusions: Recombinant growth hormone can ameliorate protein metabolism in chronic abdominal infection. IGF-1 plays important role in the ameliorated effect of recombinant growth hormone on protein metabolism in chronic abdominal infection.
