To promote colonic adaptation of short bowel rats by enteral nutrition plus fiber treatment
- VernacularTitle:肠内营养加膳食纤维对促进短肠大鼠结肠的代偿作用
- Author:
Dayong JIN
;
Jianmin XU
;
Zhaohan WU
;
Jianxing XIE
- Publication Type:Journal Article
- From:
Parenteral & Enteral Nutrition
2001;8(1):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To study the colonic adaptation of short bowel rats by enteral nutrition plus fiber treatment. Methods:The short bowel rats were randomized into two groups:feed by Pepti-2000(EN) and by Pepti-2000 plus fiber(EF);and another normal rats as control(CONT) group.The nutritional states and morphologic changes of the colon were investigated. Results:From postoperative days(PODs) 15,the weight of EF group was increasing and greater than EN group after PODs 18.The net nitrogen balance in EF group was almost the same as CONT,but greater than EN group.All the mucosal thickness,villous height and surface area of the colon in EF group were greater than CONT and EN group(P<0.001).DNA index and percentage of S phase cells of the colonic mucous in study groups were higher than CONT group(P<0.05).Also the levels of colonic mucous IGF-1 mRNA in study groups were higher than in CONT group(P<0.05). Conclusions:Enteral nutrition plus fiber can not only promote nutritional states;but enhance colonic adaptation to the short bowel rats.
