The circadian ryhthm variation of melatonin receptor in peripheral leukoc ytes in patients with acute cerebral infarction
- VernacularTitle:急性脑梗死患者外周血白细胞褪黑素受体昼夜节律的变化
- Author:
Fang CAO
;
Ying ZHAO
;
Zhongxin ZHAO
;
Zhimin LIU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(1):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the circadian ryhthm v ariation of 2-125I-iodomelatonin (125I-Mel) binding sites in the human peripheral leukocytes in patients with acute cerebral infarction. Methods: Melatonin binding sites in the human peripheral leukocytes were studied using 125 I-Mel as a radioligand (radioligand binding assays).A ll patients ［age: (70.18±11.70) years］ were diagnosed by CT according to the standard ［Chin J Nerv， 1996,29(6):379］. We also studied 15 age-match ed healthy old people as the control ［age: (68.33±7.76) years］. Resul ts: The circadian ryhthm variation of 125 I-Mel specific binding in control remained significant (P<0.01) with a higher value at midlight ［ (0.16±0.049) fmol/106］ than at middark ［(0.078±0.035) fmol/106］ with one point analysis. There was no significant variation in the patient grou p (P>0.05). The specific binding in the peripheral leukocytes at midlight in the patients with acute cerebral infarction were lower than that of the control . Conclusion: The expression of Mel receptor decreases in the pa tients wit h acute cerebral infarction and the circadian ryhthm variation of 2-125I -Mel appears abnormal.
