Inhibitory effect of ginsenoside Rg3 on tumor neoangiogenesis
- VernacularTitle:人参皂甙Rg3抑制肿瘤新生血管形成的研究
- Author:
Yong GAO
;
Jiejun WANG
;
Qing XU
;
Qinqin YE
;
Jing GUO
;
Huaicheng GENG
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(1):40-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the mechanism of inhibitory ef fect of ginsenoside Rg3 on tumor growth. Methods: The chick chor ioallantoic membrane(CAM) test and Lewis lung carcinoma model were used to inves tigate the inhibitory effect of Rg3 on tumor angiogenesis. Results: Rg3(0.1 or 0.5 mmol/L) obviously inhibited angiogenesis in the CAM. Treatmen t with Rg3 in vivo obviously inhibited Lewis lung carcinoma growth with the inhibition ratio from 23% to about 47%. We also observed that the angiogenesis in implanted Lewis lung carcinoma tissue decreased obviously after treated wit h Rg3 (5, 10, 20 mg/kg). Conclusion: Rg3 can obviously inhibit t he growth of Lewis lung cancer, the inhibitory effect partially due to the effec t of Rg3 inhibiting neovascularization induced by malignant tumor.
