Expression of P33ING1 in stomach cancer and its clinical significance
- VernacularTitle:P33ING1在胃癌组织中的表达及其意义
- Author:
Houzhong DING
;
Hairen YANG
;
Xiaofeng CAI
;
Liangbo LI
;
Caihua LI
;
Xiaoyang WU
;
Dong YANG
;
Xin LENG
;
Canrong NI
;
Minghua ZHU
;
Hai LI
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the pathological relationship between P33ING1 and stomach cancer and its clinical significance. Methods: In 71 cases of stomach cancer specimen, twelve cases of gas tric mu cous membrane atypical hyperplasia tissues and 18 cases of normal gastric mucous membrane tissue（as control）,the expression of P33ING1 were detected b y EnVision immunohistochemical method,while the expression of P53 and Bcl -2 in stomach cancer were also detected. Results: P33IN G1 expression in mucous membrane atypical hyperplasia group and control group was positive, the expression in stomach cancer group was extremely low(62.0%，44 /71), significantly different from the other 2 groups(P<0.01).P33ING1 expression in stomach cancer was related to the tumor growth, lymph node meta s tasis and tumor polarization (P<0.01), P53 expression was related to tumor s ize, growth and lymph node metastasis (P<0.01). Bcl-2 expression was relate d to lymph node metatasis and tumor polarization.The expression of P33ING1 was related to that of P53 in stomach cancer(P<0.05),while had no relation with that of Bcl-2.Conclusion:P33ING1 may play an importa nt role in the occurrance and development of stomach cancer.It's very important to detect the expression of P33ING1 and P53 simultaneously.
