Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice
- VernacularTitle:神经生长因子在小鼠体办的动力学,组织分布和排泄实验
- Author:
Caiguo HUANG
;
Shanjian WEI
;
Hua JIANG
;
Shukui SONG
;
Huiyuan LI
;
Yuanfang WU
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
2001;22(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the pharmacokinetics,thissue distribution and secretion of nerve growth factor(NGF)in mice.Methods:The conecntration of NGF in various body fluids and tissue were determined by isotope tracer combined SDSPAGE method.Results:The plasma concenmtration-time curve was in accordance with the two-compartment pharmacokinetic model.The elimation half-life(t1/2β)was 3.1.The half-life of distribution(t1/2ka)was 5min.Tpeak was 25 min.AUC was 72.4 mg·kg-1·h-1.The concentrations of NGF were high in thyroid,blood,submaxillary glands,superior cervical ganglion,adrenasl and kidneys.Conclusion:NGF has a wide distribution,high tissue concentrationa nd excrtet mainly through the urine.
