Property analysis of voltage-dependent potassium channel in human peripheral blood lymphocytes and its subset
- VernacularTitle:人外周血淋巴细胞膜电压依赖性钾通道特性分析及试分型
- Author:
Xiaoxia SUN
;
Hongchen SONG
;
Qingwei ZHOU
;
Yan HE
;
Guogan ZHONG
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(1):22-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyse the property of voltage-dependent potassium 〔K(v)〕 channel in healthy people′s peripheral lymphocyte so as to contribute the control for property alteration under some pathological condition,and to try to find the new subset of this channel.Methods:Patch-clamp whole cell recording technique was used.Results:In the recorded 39 cells,activated voltage of the channels was -40.3±2.5 Mv.No inactivation phenomenon appeared under repeated stimulation.The closing time of the channels was 116.3+8.2 ms under the repolarization,and the current could be inhibited by 10 mmol/L TEA.Conclusion:There might be only one type of K(v) channel in human peripheral blood lymphocytes,and its properties quite resumble the type of n K(v) channel in mice.
