Effect of losartan on arterial blood pressure and unit dischargings of habenular neurons in rat
- VernacularTitle:芦沙坦对大鼠动脉血压和缰核神经元自发放电活动的影响
- Author:
Yuzhen PAN
;
Yinghong XIA
;
Li YAN
;
Shao WANG
;
Shuisheng WU
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(1):29-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the habenula takes part in the depressor effect of losartan.Methods:Arterial blood pressure,heart rate and the unit dischargings of habenular neurons in rat were recorded simultaneously.Results:Arterial blood pressure was apparently decreased by 10 mg/kg losartan intraperitoneally(ip),but heart rate did not change;63.64% (21/33) unit dischargings of habenular neurons was increased in the rate of discharges.Conclusion:The depressor effect of losartan (ip) may be involved in the excitation of habenular neurons by lsoartan(ip).
