Effects of oxymatrine on sodium current in isolated ventricular cells in guinea-pig
- VernacularTitle:氧化苦参碱对豚鼠心室肌细胞钠电流的影响
- Author:
Xia CHEN
;
Yingji LI
;
Wenjie ZHANG
;
Jingyan GE
;
Guogan ZHONG
- Publication Type:Journal Article
- From:
Journal of Jilin University(Medicine Edition)
2001;27(1):41-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Effects of oxymatrine on the sodium current were studied .Methods:The whole cell voltage clamp technique was used in isolated ventricular cells of guinea-pig.Results:Oxymatrine (0.1,0.3 and 1 mmol/L) showed inhibition to the sodium current in dose-dependence.Conclusion:These results indicate that inhibition of oxymatrine to the sodium current may be one of mechanisms of its antiarrhythmic action.
