Effects of inducers of differentiation on telomerase activity in malignant cells
- VernacularTitle:细胞分化诱导剂与端粒酶活性调控
- Author:
Liming ZHANG
;
Qian HE
;
Guang YANG
;
Zhilong CHEN
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(2):140-142
- CountryChina
- Language:Chinese
-
Abstract:
More than 85% of all cancers express telomeras e activity. Human telome rase has been proposed as a novel and potentially highly selective target for ca ncer therapy. Inducers of differentiation are involved in regulation of telomera se activity. In the present review, the effects of retinoids, vitamin D3 compo unds, tea catechins and matrine on telomerase activity in malignant cells were r eviewed.
