The role of 5-HT in antinocieption produced by intrathecal indomethacin in mice
- VernacularTitle:小鼠鞘内注射吲哚美辛的镇痛作用与5-羟色胺的关系
- Author:
Zhongning ZHU
;
Liuyi DONG
;
Zhiwu CHEN
;
Biwei SONG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(2):217-219
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the role of 5-HT in antinocieption produced by intrathecal indomethacin (Ind) in mice. METHOD The antinocieption of indomethacin was investigated on the tail immersion test in mice；the contents of 5-HT, 5-HAA were assayed with fluorescent method. RESULT Dose-dependent antinocieption was observed following intrathecal administration of Ind 1.8 mg*kg-1, the effect could be obliterated when the animals were pretreated with cyproheptadine. After intrathecal administration of Ind, the content of 5-HIAA in the spinal cord of mice was significantly increased, but PG had no effect. CONCLUSION The result imply that intrathecal indomethacin could produce antinocieption; this effect is mediated by 5-HT. PG does not participate in the action of 5-HT.
