Protective effect of taurine on diaphragm against adriamycin cytotoxicity
- VernacularTitle:牛磺酸对阿霉素致膈肌毒性的保护作用
- Author:
Sudong GUAN
;
Min GE
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(2):220-222
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study protective effect of taurine on diaphragm against adriamycim cytotoxity in rabbits.METHODS The rabbits were divided randomly into three groups.①Control group:The animals were administered NS 2 ml*kg-1 for five days. ②Adriamycin+NS group:The animals were administered NS 2ml*kg-1 for five days and then administered adriamycin 10 mg*kg-1.③Adriamycin+taurine group:The animals were administered taurine 100 mg*kg-1 for five days and then administered adriamycin 10 mg*kg-1.After 24 h,three groups animals were anaesthetized.The transdiaphragmatic pressure(Pdi) and diaphragm evoked potential(DEP) were measured.SOD and MDA were tested.the ultrastructure of diaphragm cells was investigated by eletronmicroscopy.RESULTS The Pdi and amplitude of DEP were lowered by adriamycin(P＜0.01).The levels of MDA was increased and the activity of SOD was decreased in diaphragm(P＜0.05).The disorder of myofibrills,swelling of mitochondria with broken cristase can be observed by electronmicroscopy.The above changes were inhibited by taurine.CONCLUSIONS The taurine could scavenge the toxic radicals generated by adriamycin and protect the diaphragm myocytes.
