The protective effects of TGP on local cerebral ischemia in rat
- VernacularTitle:白芍总苷对大鼠局灶性脑缺血的保护作用
- Author:
Huapu WU
;
Xiaoguang ZHU
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
2001;17(2):223-225
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the protective effects of TGP on local cerebral ischemia. METHODS The local cerebral ischemia in rat was made by middle cerebral artery occlusion(MCAO). The infraction weight was determined by NBT stain. SOD, MDA and apoptosis were determined with different method respectively. RESULTS TGP 20 mg*kg-1 ip markedly improved the abnormal nervous symptoms, increased the SOD activity and reduced contentes of MDA in MCAO rat. TGP 20 mg*kg-1 ip significantly decreased the numbers of apoptotic cells in ischemic cortex. CONCLUSION TGP has protective effects against cerebral infarction, and its mechanism may be related to anti-apoptosis and free radical.
