Study on Pharmacokinetics of Aclacinomycin A Polylactide Lyophilized Nanoparticle in Plasma of Rabbit
- VernacularTitle:阿克拉霉素A聚乳酸毫微粒冻干针剂在兔体内的血浆药动学研究
- Author:
Lin HE
;
Xuehua JIANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(2):80-81
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics of aclacinomycin A polylactide lyophilized nanopartical (ACM-A-PLA-NP) in plasma of rabbit.METHODS:HPLC was selected to determine the concentration of aclacinomycin A in plasma after a single dose of ACM-A-PLA-NP and lyophilized ACM-A.RESULTS:The pharmacokinetic parameters of these two dosage forms were obtained by 3p87.CONCLUSION:The lyophilized ACM-A-PLA-NP has a more sustained release character comparing with the lyophilized ACM-A.
