Effect of Levofloxacin on Pharmacokinetics of Phenytoin Sodium in Rabbits
- VernacularTitle:左旋氧氟沙星对苯妥英钠在家兔的药代动力学影响的研究
- Author:
Linqing HUANG
;
Zhiyong YANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(2):83-84
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of levofloxacin(LVFX)on serum concentrations and pharmacokinetics of phenytoin sodium(PHT)in rabbits.METHODS:Using UV-spectrophotometry,the serum concentrations of PHT were determined in nine rabbits before oral feeding LVFS and after a single dose of PHT given iv 10 days later.The pharmacokinetic parameters were worked out with 3p87 program.RESULTS:The concentration-time curve of PHT was fit to open two-compartment model.After co-administration of LVFX,the serum concentrations of PHT were decreased to some extent and part of pharmacokinetic parameters obviously changed as well.CONCLUSION:Co-administration of PHT and LVFX will accelerate the metabolic process of PHT.
