Analysis of 1 230 Cases Developing Adverse Reactions to Antibiotics
- VernacularTitle:1230例抗生素不良反应分析
- Author:
Xiaohua YANG
- Publication Type:Journal Article
- From:
China Pharmacy
2001;12(2):106-107
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE：To investigate the general patterns and characteristics of ADRs to antibiotics and to guide rational drug use.METHODS：Using literature metrological method，1 230 cases developing drug adverse reactions to antibiotics,reported in Chinese literatures in the past 10 years,were analysed.RESULTS：ADRs to antibiotics of the 1 230 cases accounted for 46.19％ of all sorts of drug adverse reactions in the same time period.Among the antibiotics,β-lactam antibiotics were number one in kind(18 kinds),those happened most frequently were ampicillin(192 cases).The most frequent adverse reactions were damages to the skin and its appendages and the most serious reaction was anaphylactic shock,of which 76.15％ (83/109) was caused by β-lactams.Since the T cells are offen activated by drugs resulting in release of cytokines,which are the key to understand drug adverse reactions51.79％ (29/56)of renal dysfuncition was caused by aminoglycosis,therefore,attention should be paid to them.CONCLUSION：Attention to the rational use of antibiotics is essential,so as to reduce abuse use and damage to patients by irrational drug administration.
