Protective effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxy-phenylethylamino) propane hydrochloride on brain ischemia and reperfusion injury in mice
- VernacularTitle:1-(2,6-二甲基苯氧基)-2-（3，4-二甲氧基苯乙氨基）丙烷盐酸盐对小鼠脑缺血再灌损伤的保护作用
- Author:
Weiting WANG
;
Lianjun GUO
;
Ling QU
;
Fang WANG
;
Qing LU
;
Jiaqing QIAN
- Publication Type:Journal Article
- From:Chinese Journal of Pharmacology and Toxicology
2001;15(2):137-140
- CountryChina
- Language:Chinese
-
Abstract:
By using decapitating, intravenous injection of saturated MgCl2 and legation of bilateral carotid arteries with vagi, the effects of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethyl- amino) propane hydrochloride(DDPH) on survival time in mice were studied. With the model of cerebral ischemia for 20 min and reperfusion for 10 min, effects of DDPH on the superoxide dismutases(SOD) activity and malondialdehyde (MDA) content in brain tissue and pathological changes were studied. The results indicated that DDPH at dosages of 3,6,12,24 mg*kg-1 ip 30 min before ischemia prolonged the survival time significantly. Meanwhile, DDPH was found to increase the activity of SOD and reduce the content of MDA, as well as mitigate pathological damage of neuron after cerebral ischemia and reperfusion in mice. The results suggest that DDPH has protective effects on brain ischemia.
