Dynamic Study of Fas Expression and Cell Apoptosis in the Cerebral Ischemic Tissues
- VernacularTitle:鼠缺血脑组织中Fas 抗原表达及细胞凋亡的动态研究
- Author:
Xiaoguang LUO
;
Li XIAO
;
Ming ZHU
;
Hengchun QU
;
Yingxue NIE
;
Xin JIANG
;
Shaoying LI
;
Chaodong ZHANG
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(2):96-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Our purpose was to study the relationship between the Fas antigen expression and neuron apoptosis after cerebral ischemia. Methods: We detected the Fas antigen expression and neuron apoptosis dynamically in the animal models with cerebral ischemia by immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method. Results: Fas antigen was positive after 30 minutes of ischemia and reached peak at 60 minutes. At the 24th hour, it began to decrease, and negative on the 3th day. While the positive cell for TUNEL method appeared after 60 minutes of ischemia, reached peak on 3 day, and decreased on 7 day. Conclusion: Neuron apoptosis after cerebral ischemia is closely related to the over-expression of Fas antigen.
