A study for HSPG gene polymorphism in Chinese type 2 diabetic ne phropathy
- VernacularTitle:硫酸乙酰肝素蛋白多糖基因多态性与糖尿病肾病关系的研究
- Author:
Tao YANG
;
Jiawei CHEN
;
Jie SHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Diabetes
2001;9(2):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between th e heparan sulfate proteoglycan gene (HSPG) polymorphism and diabetic nephropathy in Chinese.Methods A case control study of 326 Chinese s ubjects including 136 type 2 diabetics with or without nephropathy and 190 non- diabetic control was performed.Genotype frequencies of HSPG2 polymorphism were s tudied by PCR-RFLP analysis with BamHI digestion.Results There was no difference in genotype frequencies or allele frequencies between normal albuminuria and abnormal albuminuria patients.Moreover,there was no assoc iation between diabetic patients and non-diabetic control in allele frequencies as well,but obvious difference in genotype frequencies(0.05＞P＞0.025) was found.Conclusion Our study showed the lack of association between HSPG polymorphism and diabetic nephropathy in Chinese type 2 diabetics. There may be association between genotype frequencies of HSPG polymorphism and d iabetes in statistics.
