Effects of propofol, midazolam and thiopental sodium on outcome of focal cerebral ischemia-reperfusion in rats
- VernacularTitle:丙泊酚、咪达唑仑和硫喷妥钠对大鼠局灶脑缺血再灌注的影响
- Author:
Lianhua CHEN
;
Qinyan GONG
;
Zhang YU
;
Yinzhi CHEN
;
Changsi XIAO
- Publication Type:Journal Article
- From:
Chinese Journal of New Drugs and Clinical Remedies
2001;20(2):81-86
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of propofol, midazolam and thiopental sodium on neurologic and histologic outcome from focal cerebral ischemia-reperfusion in a rat model of reversible middle cerebral artery occlusion (MCAO). METHODS: Male SD rats were scheduled to undergo 3 h MCAO by intraluminal suture and 24 h reperfusion. Neurologic outcome was scored with a 0-5 grading scale. Infarct volume was shown with TTC staining and measured by image analysis system. Ultrastructure of the tissues taken from the brim of the damaged area was examined under electron microscope. RESULTS: Both propofol and midazolam could attenuate neurologic deficits, reduce infarct and edema volumes, and ameliorate ultrastructure damage at the brim of lesion. Propofol showed better neuroprotection than midazolam while thiopental sodium did not exhibit protective effect. CONCLUSION: Propofol and midazolam, but not thiopental sodium, can provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia.
