Antipyretic, analgesic and antiinflammatory actions of dexketoprofen in experimental animal
- VernacularTitle:右酮洛芬对实验动物的解热镇痛和抗炎作用
- Author:
Yunfang ZHANG
;
Jun LI
;
Yong JIN
;
Shuyun XU
- Publication Type:Journal Article
- From:
Chinese Journal of New Drugs and Clinical Remedies
2001;20(2):103-106
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the antipyretic, analgesic and antiinflammatory actions of dexketoprofen. METHODS: Hot-plate and tail-flick models in mice, fever model in rats and rabbits induced by carrageenin or typhoid vaccine respectively, ear swelling induced by dimethylbenzene in mice; foot pad swellings induced by carrageenin and granuloma induced by cotton in rats were adopted. RESULTS: Dexketoprofen (7.5,15,30 mg*kg-1) could significantly prolong latency of analgesic in hot-plate and tail-flick models in mice and reduce carrageenin-induced fever in rats, and inhibit dimethylbenzene-induced ear swelling in mice. Dexketoprofen (1.9,3.8,7.5 mg*kg-1) could significantly inhibit typhoid vaccine-induced fever in rabbits; Dexketoprofen (3.8,7.5,15 mgkg-1) could also significantly inhibit the swelling of foot pad induced by carrageenin, and the granuloma induced by cotton in rats. CONCLUSION: Dexketoprofen has antipyretic, analgetic and antiinflammatory effect.
