Expression of p73 Protein in Giant Cell Tumor of Bone
- VernacularTitle:p73在骨巨细胞瘤中表达的意义
- Author:
Zhuang HAN
;
Min WANG
;
Gang Lü
;
Xue ZHANG
;
Yanduo JIANG
;
Chuanhai SUN
;
Jun CUI
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(2):135-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Our aims were to study the expression of p73 protein in giant cell tumor of bone, and to investigate its function in the carcinogenesis and development of giant cell tumor of bone. Methods: The expression of p73 was detected by using S-P immunohistochemical method in 40 cases of paraffin-embedded sections of giant cell tumor of bone. Results: The positive rate of p73 in 40 patients with giant cell tumor of bone was 30.0%,and 20.0% in osteochondroma.The difference between them was not significant(P<0.05). There was significant difference between the expression of p73 in different stages of giant cell tumor of bone(P>0.05). Conclusion: The expression of p73 in giant cell tumor of bone increased prominently in this experiment. It suggests that p73 may play an important role in the carcinogenesis and development of giant cell tumor of bone, and p73 may also have a certain value for the diagnosis of giant cell tumor of bone.
