Mechnisms of ischemia/reperfusion injury in transplanted liver
- VernacularTitle:移植肝再灌注损伤的发生机制
- Author:
Tanlei SHAO
;
Weiyiao CAI
;
Hongwei LI
- Publication Type:Journal Article
- From:
Chinese Journal of General Surgery
2001;10(2):173-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To introduce the research trence of the medchnisims of ischemia/reperfusion(I/R) injury in transplanted liver(TL). Methods Making a literature summarization based on papers review.Results The main mechnisms of I/R injury in TL as the followings: (1) Production of various cytokines resulted from endothelial cell injury with activation of kupffer cells, which can result in TL injury and induce systemic inflammation syndrom. (2) White blood cells and platelets adhere to the liver sinusoid (LS), which can cause TL injury and obstruct the LS causing “no reperfusion" of TL. (3) Alteration of pH in the cells of TL. After recovery of normal metabolism of the reperfused TL, alteration of pH in the TL can cause damage to TL cells, and cause edema of mitochrondria resulting in decresing of TL function. (4) Reoxygenation injury mainly caused by activated oxygen relsased by white blood cell. Conclusions I/R injury of TL is caused by combination of muttiple foctors. Improving the activity of hepatocytes and endothelial cells, imhibiting the activation of kupffer cells, decreasing the production of activated oxygen and TNF are the key points in preventing I/R injury of TL.
