The hemostatic and protective effect of human fibrin sealant on liver trauma in rats
- VernacularTitle:人纤维蛋白胶对大鼠肝损伤的止血护创作用
- Author:
Shaoqing XIA
;
Han CHEN
;
Yudong QIU
;
Yi XUE
- Publication Type:Journal Article
- From:
Chinese Journal of Biochemical Pharmaceutics
2001;22(2):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Purpose The aim is to investigate the hemostatic and protective effect of fibrin sealant(FS) on liver trauma in rats.Methods On the surface of cracked wound(type Ⅰ) and resected wound(type Ⅱ)，spraying of FS or thrombin or direct suturation, was used receptively. Natural hemostasis was used as control.During postoperation the hemostatic time and the state of wound healing on 1st, 4th, 7th,14th, 50th day were observed.Results Compared with the natural hemostasis,the hemostatical time of the FS group was shorter 86.0%(P＜0.01)in liver trauma type Ⅰ and 79.0%(P＜0.01)in liver trauma type Ⅱ.Compared with the thrombin group,the hemostatical time of the FS group was shorten 45.0%(P＜0.01)in liver trauma type Ⅰ and 84.0%(P＜0.05) in liver trauma type Ⅱ.The wound surface of FS group was healed faster than that of other groups.Conclusion FS was an effective hemostatic and healing-promoter on liver trauma of rats.
