Investigation of complement C4A and C4B deficiency in schizophrenia.
- VernacularTitle:精神分裂症与补体第四成份C4A及C4B基因缺陷关联性研究
- Author:
Yichang CHEN
;
Jiaqiang CHEN
;
Liangcheng ZHANG
;
Jiaobi CAI
;
Xinrao WU
- Publication Type:Journal Article
- From:
Chinese Journal of Nervous and Mental Diseases
2001;27(2):103-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association between the gene of complement C4A, C4B deficiency and schizophrenia. Methods 192 patients with schizophrenia and 142 healthy controls were tested with the amplification restriction fragment length polymorphism (Amp-RFLP) technique.Results The frequency of C4AQ0/C4AQ0 homozygote was higher in the patient group than in the control group (χ2=8.54, P＜0.01). The relative risk (RR) of C4AQ0/C4AQ0 homozygote for schizophrenia was 6.8. There was no increased frequency of C4B deficiency in patients with schizophrenia (χ2=0.11, P＞0.05, RR=0.73).Conclusions These results indicate that there is a positive association between complement C4A dificiency and schizophrenia. Moreover, our study did not support a widespread association between a deficiency in complement component C4B and schizophrenia.
