99mTc-TRODAT-1 SPECT imaging of dopamine transporter in early diagnosis of Parkinsons disease.
- VernacularTitle:99m Tc-TRODAT-1 SPECT多巴胺转运体显像对帕金森病早期诊断的价值
- Author:
Weifeng LUO
;
Shiyao BAO
;
Jinchang WU
;
Yu FU
;
Chunfeng LIU
;
Guofu SHAO
;
Ping FANG
- Publication Type:Journal Article
- From:
Chinese Journal of Nervous and Mental Diseases
2001;27(2):106-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of 99m Tc-TRODAT-1 SPECT DAT imaging in the early diagnosing of Parkinsons disease (PD).Methods Eleven patients (9 PD and 2 possible PD) and eighteen healthy subjects matched by sex and age were studied with 99m Tc-TRODAT-1 SPECT DAT imaging. Striatum specific uptake of 99mTc-TRODAT-1 was calculated according to the ratio of DAT uptake in striatum (ST) and cerebellum (CB). Results In the hemi-Parkinsons disease group, the DAT specific uptake of 99mTc-TRODAT-1 was significantly lower (P＜0.01) in contralateral than in ipsilateral striatum to the clinically symptomatic side. There was significant decrease (p＜0.01) of striatum DAT uptake in patients with hemi-PD compared to the controls.Conclusions 99mTc-TRODAT-1 SPECT DAT imaging may help to confirm the diagnosis of PD at the early stage.
