The Revaccination Effect of Domestic Yeast-derived Recombinant Hepatitis B Vaccine

VernacularTitle:用国产重组酵母乙型肝炎疫苗进行再免疫的效果观察
Author: Zhenhai WANG ; Shunyuan ZHU ; Zuyun WU
Publication Type:Journal Article
From: Chinese Journal of Vaccines and Immunization 2001;7(2):100-102
CountryChina
Language:Chinese
Abstract: This paper was to observe the revaccination effect of domestic yeast-derived recombinant hepatitis B vaccine (YRHBV) to children who were born to HBsAg and HBeAg negative mothers and had been immunized with full course of blood-derived hepatitis B vaccine 4 years ago at their birth. The treated group was revaccinated with 5μg YRHBV while the control group with 10μg blood-derived HB vaccine, their anti-HBs response was determined 1,12,24 months after revaccination. The results showed that a nice anti-HBs response was discovered in group A childeren, no matter how about the anti-HBs level before revaccination was. The kinetics of anti-HBs after YDHBV revaccination was similar to that of the blood-derived HB vaccine, no statistical difference was found. So, 5μg of domestic yeast-derived recombinant HB vaccine gave same immune effect as well as 10μg blood-derived HB vaccine.