Expression of p16 and CDK4 in human lung carcinoma
- VernacularTitle:细胞周期调控因子p16和CDK4在肺癌中的表达
- Author:
Mingzhi LU
;
Yong LIU
- Publication Type:Journal Article
- From:
China Oncology
2001;11(2):123-124
- CountryChina
- Language:Chinese
-
Abstract:
Purpose：To study the expressions of p16 and CDK4 in human lung carcinoma. Methods：By using S-P immunohistochemical methods, the expressions of p16 and CDK4 in 62 cases of human lung carcnoma were studied. Results：The postive expressions for p16 and CDK4 protein were 58.1% and 48.4% respectively. A significant correlation was found between CDK4 overexpression and lymph node metastasis (P＜0.01). A significant correlation between the under expression of p16 and overexpression of CDK4 was found.Conclusions：The results suggested that CDK4 overexpression plays an important role in metastasis of lung carcinoma.
