Patterns of p53 expression in phyllodes tumors of the breast: an immunohistochemical study.
10.3346/jkms.1993.8.5.325
- Author:
Chong Jai KIM
1
;
Woo Ho KIM
Author Information
1. Department of Pathology, Seoul National University College of Medicine, Yongon-dong, Chongno-gu, Korea.
- Publication Type:Original Article
- Keywords:
p53;
Phyllodes tumor;
Cystosarcoma phyllodes;
Breast neoplasm
- MeSH:
Adult;
Breast Neoplasms/*chemistry/pathology;
Female;
Genes, p53;
Humans;
Immunohistochemistry;
Middle Aged;
Phyllodes Tumor/*chemistry/pathology;
Tumor Suppressor Protein p53/*analysis
- From:Journal of Korean Medical Science
1993;8(5):325-328
- CountryRepublic of Korea
- Language:English
-
Abstract:
Authors performed an immunohistochemical analysis using monoclonal antibody to p53 protein on 15 cases of benign and malignant phyllodes tumor of the breast along with a review of other conventional clinicopathological parameters to investigate the meaning of p53 expression. The cases were composed of 8 benign and 7 malignant lesions. The pattern of p53 expression showed a statistically significant difference between these benign and malignant lesions (p<0.005). None of the benign cases expressed p53 whereas 6 out of 7 malignant cases did. Among malignant phyllodes tumors, the pattern of expression was diffuse and strong in two cases while granular and relatively weak in the remaining 4 cases. p53 expression seemed to be a unique feature of malignant phyllodes tumors, thereby, one of the most significant parameters for the differentiation of benign and malignant phyllodes tumors of the breast.
