SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-[(SUBSTITUTED PHENYL)VINYL] INDOLE DERIVATIVES
- VernacularTitle:2-(取代苯乙烯基)吲哚类衍生物的合成及其生物活性
- Author:
Li XU
;
Shiping XU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):100-104
- CountryChina
- Language:Chinese
-
Abstract:
AIM To synthesize derivatives of 2-[substituted phenyl)vinyl] indole and find compounds with biological activities by screening in vitro. METHODS Twenty-one compounds of 2-[(substituted phenyl)vinyl] indole were synthesized by reduction, oxidation and Witting reaction. MS, 1HNMR and elemental analysis were used to determine the structures of the new compounds. RESULTS These compounds are new ones. CONCLUSION Six compounds (3,9,11,13,18 and 20) showed effects on some different receptors, such as alpha2, D2 and H1, and is worth further studying.
