SYNTHESIS AND ACTIVITIES OF 4-DEOXY-4β-ARYLMEHTYLENE SULFONYLAMIDO-4′-DEMETHYLPODOPHYLLOTOXINS
- VernacularTitle:4-去氧-4β-芳甲磺酰胺基-4′-去甲鬼臼脂素的合成及体外抑制肿瘤细胞活性
- Author:
Yong HE
;
Weiyong MA
;
Xiuhua CHEN
;
Chunnian ZHANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
AIM To find new anticancer drug based on the structure of podophyllotoxin. METHODS AND RESULTS 4-Deoxy-4β-arylmethylenesulfonylamido-4′-demethylpodophyllotoxins were (1-15) synthesized and their antitumour activities against KB cells and L1210 leukemia cells were tested. CONCLUSION These compounds are new compounds. Among them, compounds 2, 3, 8, 9, 11 and 12 showed antitumour activities. When halides exist on the aryl ring of substituted sulfonyl group, the corresponding compound has relatively higher activities. The stereo factor is important for the activities.
