STUDIES ON THE GLYCOCONJUGATES AND GLYCANS FROM LYCIUM BARBARUM L IN INHIBITING LOW DENSITY LIPOPROTEIN (LDL) PEROXIDATION
- VernacularTitle:枸杞子糖缀合物及其糖链对LDL氧化修饰的抑制作用
- Author:
Linjuan HUANG
;
Gengyuan TIAN
;
Zhongfu WANG
;
Jibin DONG
;
Manping WU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):108-111
- CountryChina
- Language:Chinese
-
Abstract:
AIM To determine the effects of glycoconjugates and their glycans from Lycium barbarum L. on inhibiting low density lipoprotein (LDL) peroxidation. METHODS Using Cu2+-induced oxidation as a model, the oxidative production of thiobarbituric acid-reactive substances (TBARS) and the LDL electrophoresis migration on agarose gel were measured. RESULTS The effects of glycoconjugates and their glycans from Lycium barbarum L. on inhibiting LDL peroxidation were different, among them, glycoconjugate LbGp5 showed the best effect on inhibiting LDLperoxidation. CONCLUSION The glycoconjugates can inhibit LDL peroxidatin while their glycans showed no effects on inhibiting LDL peroxidation.
