ELECTROCHEMICAL BEHAVIOR OF OFLOXACIN AT Pt/GC ION IMPLANTATION MODIFIED ELECTRODE AND ITS APPLICATION
- VernacularTitle:氧氟沙星在Pt/GC离子注入修饰电极上的电化学行为及其应用
- Author:
Yonggui QIAN
;
Yiqiang LU
;
Jingbo HU
;
Yanning MAO
;
Qilong LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the electrochemical behavior of ofloxacin at Pt/GC ion implantation modified electrode. METHODS With Pt/GC ion implantation modified electrode as working electrode, the behavior of ofloxacin was studied by voltammetry in 0.40 mol*L-1 KCl solution. RESULTS A sensitive reductive peak of ofloxacin was obtained by linear sweep voltammetry. The peak potential was -1.35 V (vs SCE). The peak current was proportional to the concentration of ofloxacin over the range of 1.0×10-6-3.0×10-5 mol*L-1 with the detection limit of 5.0×10-7 mol*L-1. The behavior of reduction wave was studied and applied to determination of ofloxacin in tablets. CONCLUSION The reduction process was irreversible. The element composition, atomicity form and depth of distribution at the surface of Pt/GC electrode were determined by Auger electron spectroscopy (AES), X-ray photoelectron spectroscopy (XPS) and scannig electron microscope (SEM). The catalysis behavior and reaction mechanism at Pt/GC modified electrode was also studied.
