PHARMACOKINETICS AND BIOAVAILABILITY OF CLINAFLOXACIN IN RATS
- VernacularTitle:克林沙星在大鼠体内的药代动力学和生物利用度
- Author:
Meihua ZHOU
;
Yunqiu YU
;
Gengli DUAN
;
Wuben CHENG
;
Changjiang XU
;
Xiao LIU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):134-136
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the pharmacokinetics and bioavailability of clinafloxacin in rats. METHODS The drug concentration was determined by HPLC. The main pharmacokinetic parameters were obtained by 3P87 program. An RP-C18 was used as the stationary phase. The mobile phase was a mixture of acetonitrile-0.05 mol*L-1 citric acid triethylamine (pH 2.5) (20∶80). The flow rate was 1.0 mL*min-1. The UV absorbance detector was set at 300 nm. RESULTS A good linearity was obtained from 0.03-20 μg*mL-1 of clinafloxacin in rat plasma with γ=0.9998. The plasma concentration-time curve of clinafloxacin conformed to one compartment open model. After ig administration of 50 mg*kg-1 and 100 mg*kg-1 dose of clinafloxacin in six rats, mean Cmax and AUC values increased in proportion to dose. Mean T1/2 appeared to be independent of dose. Mean AUC was 65±6 and 27±4 μg*h*mL-1 respectively after iv and ig adminostration of 100 mg*kg-1 dose. The extent of bioavailability (F) of clinafloxacin was 42%. CONCLUSION The results of the pharmacokinetic study of clinafloxacin showed that it exhibited first order kinetic characteristics and the bioavailability is low.
