ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT
- VernacularTitle:7-(4-氯苄基)-7,8,13,13a-四氢小檗碱在家兔体内的代谢产物分析
- Author:
Nianping FENG
;
Zhengxing ZHANG
;
Dengkui AN
;
Xiuwen HAN
;
Wenlong HUAN
;
Guangji WANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2001;36(2):137-139
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
