Change of peripheral blood CD5+B cells in hepatitis B patients and its association with indexes of liver function
- VernacularTitle:乙型肝炎患者外周血CD5+B细胞的变化及其与肝功能指标的相关性
- Author:
Ruining YANG
;
Fangqiu LI
;
Jianguo WU
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(2):99-102
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To explore the change of peripheral blood CD5+B cells and its association with indexes of liver function in patients with hepatitis B.Methods:Change of peripheral blood CD5+B cells was detected immunohistochemically.The indexes of liver function were examined by HITAI 7170 automatic analyzer.Results:There were no significant differences in the percentage of peripheral blood CD5+B cells between patients with acute hepatitis B and normal controls.With the severity development of hepatitis B from chronic hepatitis to cirrhosis,the percentage of peripheral blood CD5+B cells is positively correlated with the increase of ALT，AST，GGT，TB and ALB.Conclusions:A large number of CD5+B cells are activated in patients with chronic hepatitis B,heavy chronic hepatitis or cirrhosis.The percentage of peripheral blood CD5+B cells increases concomitantly with the liver impairment.
