Protective effect of ciliary neurotrophic factor on spinal neurons
- VernacularTitle:睫状神经营养因子对损伤脊髓神经元酶学的影响
- Author:
Bin XU
;
Hong WU
;
Lianshun JIA
;
Jiashun LI
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To study the enzymatic changes and protective effects of ciliary neurotrophic factor (CNTF) on neurons in spinal cord injury (SCI).Methods:SD rats were subjected to incomplete SCI with modified Allen methods.Activities of acetylcholinesterase (AChE) and acid phosphatase (ACP) in spinal cord were quantitatively measured preoperatively,and 3,7,14 days after SCI.Results:AChE activity decreased gradually after injury.ACP activity increased 3 days after injury,and reached peak on the 7th day,then recovered gradually.The rats treated with CNTF showed relatively smooth change of the 2 kinds of enzymes.Conclusions:CNTF plays a role in protecting the spinal cord neurons against injury.
