Histogenesis and cell differentiation of desmoplastic ameloblastoma
- VernacularTitle:促结缔组织增生型成釉细胞瘤的组织发生与细胞分化机制探讨
- Author:
Jiang LI
;
Weiguo ZHANG
- Publication Type:Journal Article
- From:
Journal of Practical Stomatology
2001;17(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the histogenesis and cell differentiation of desmoplastic ameloblastoma.Methods:The expression of various protein filaments was detected by immunohistochemical stainning in 20 cases of desmoplastic ameloblastoma and the ultrastructure of the tumor was observed in 4 cases.Results:CKH,CK8 and CK19 were positive in spindle-shaped and polygonal epithlium tumor cells.Vimentin was positive in mesenchymal fibrocytes and smooth muscle actin in some mesenchymal cells.Ultrastructural observation found that tonifilaments were in epithelial cells and there were desmosomes between these cells.In stroma myofibroblasts were presented.Loose connective tissue could be seen around some epithelial cell nests.Conclusion:Desmoplastic ameloblastoma may be arise from the early stage of the dental germ formation, epithelial cells of the tumor had the tendency to differentiate to the keratinized cells.
