Changes of Cardiac Function in CHF rats after Blocking the Renin Angiotensin-Aldosterone System at Different Sites
- VernacularTitle:阻断肾素-血管紧张素-醛固酮系统对慢性充血性心衰大鼠心功能的影响
- Author:
Quanxin LIANG
;
Ruizhen CHEN
;
Yingzhen YANG
;
Naisheng CAI
;
Ying HU
- Publication Type:Journal Article
- From:
Fudan University Journal of Medical Sciences
2001;28(2):136-138
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo observe the effects of blocking the renin-Angiotensin-Aldosterone system at different sites in experimental congestive heart failure (CHF)rats. Methods Six weeks after coronary ligation, rats( n = 66)were randomized to benalapril, losartan, spironolactone, placebo, and treated for 6 weeks. Sham-operated rats( n = 18) served as controls. Six weeks later left ventricular hemodynamics were measured. Results In the hemodynamic variables, HR was not significantly different between groups. Compared four treatment groups with sham-operated group, LVEDP increased, LVPSP and ± dp/dtmax decreased (P＜0.05). Compared with placebo group,all data in spironolactone group were not significantly different, LVEDP, mortality in benalapril group and in losartan group decreased, LVPSP and ± dp/dtmax in benalapril group and in losartan group increased(P ＜ 0.05). ConclusionsAdministration of ACEI and Ag Ⅱ-AT1 antagonist are effective in preventing from cardiac function deterioration, while spironolactone treatments are not. Spironolactone has tendency in decreasing LVEDP.
